Tag Archives: CDI

Zinplava has been launched by MSD in the UK

MSD has launched Zinplava in the UK, offering patients a novel therapeutic option for the prevention of Clostridium difficile recurrence.

Zinplava (bezlotoxumab) is not an antibacterial and is not indicated to actually treat the infection, but is a monoclonal antibody designed to neutralise C. difficile toxin B, which can damage the gut wall and cause inflammation, leading to diarrhoea.

It is the first and only EC licensed non-antibiotic option indicated to prevent recurrence of Clostridium difficile infection (CDI) in high-risk adults.

Around one-in-four patients experience a recurrence after the initial episode, and more than 40 percent of these have further recurrence, highlighting the need for new options able to break the infection cycle.

Pivotal Phase III clinical studies showed the rate of infection recurrence through week 12 to be significantly lower in patients given Zinplava (17.4 percent and 15.7 percent) or Zinplava and actoxumab (15.9 percent and 14.9 percent) than those taking a placebo (27.6 percent) and (25.7 percent), respectively.

“Notably, bezlotoxumab reduces the risk of the recurrence of CDI for at least 3 months, compared with standard of care antibiotic therapy. This is welcome addition to our limited options to reduce the considerable morbidity and mortality associated with CDI,” commented Mark Wilcox, Professor of Medical Microbiology at the University of Leeds.

“Antimicrobial resistance is a key national issue and we hope with bezlotoxumab to not only help achieve a reduction in the number of recurrent episodes of CDI but also a reduction in the amount of antibiotic prescriptions that would otherwise be needed to treat these recurrent episodes,” added Dr Mike England, MSD’s Interim Medical Director.

Zinplava is administered as a single, one-off, one-hour intravenous infusion alongside standard-of-care antibiotic therapy for the treatment of CDI.

 

C Diff Foundation and C diff Survivors Alliance Network Share a Winter 2017 Bulletin

Greetings from the main office of the C Diff Foundation and the C diff Survivors Alliance Network located in New Port Richey, Florida.  As we close 2017 we mark the 5th anniversary of the two organizations. We want to share with you a summary and reflection on this year’s events and campaigns moving our mission forward and message delivered worldwide. The mission and promoting C.diff. Awareness has been shared this year with  listeners in over 25 Counties during Season III on C. diff. Spores and More Global Broadcasting Network (www.cdiffradio.com),  5,000+ visitors during global events, 9,600+ residents and business owners throughout villages and communities by our dedicated volunteer patient advocates, to over 1,000 clinicians who received up-to-date data expanding their knowledge during workshops and local symposiums offered worldwide, 3,000+ incoming calls received through the Nationwide Hot-Line 1-844-FOR-CDIF with the thousands of e-mails received seeking assistance.

After each event, workshop, meeting, introduction we thank the individuals for sharing  in five years of opportunity to provide life-saving data educating and advocating for C. difficile infection prevention, treatments, environmental safety and support worldwide.  The mission of the C Diff Foundation is the momentum of charity that has proven effective and grown over the past five years.  A single act of charity grows into more and greater charity worldwide.  The work each member of the C Diff Foundation, with hundreds of Volunteer Patient Advocates, promote the Foundation’s mission which never stops with a single act.  Instead, it builds, it grows, and it expands into an exponential impact of good in the world helping to save lives.  We thank you for your continued support and encourage you to continue your journey, proposing three verbs important to the C Diff Foundation and the C diff Survivors Alliance Network in general.

The first of these verbs is “to promote” C.diff. Awareness. It is the first step that opens doors in educating individuals, clinicians, communities in learning more about this life-threatening infection which causes a great amount of pain and suffering around the globe.  It is essential and it is the compass in reaching shared goals.

The second verb is “to heighten awareness” across the nation to continue proclaiming November Clostridium difficile infection awareness month. The Governors proclaimed November C. difficile (C.diff) infection awareness month in 2017 and we encourage them “to welcome” this proclamation in 2018 with more than a yearly executive order of greeting or inviting their residents to take notice.  We look forward to working with delegates, with your support, to make this proclamation statement nationwide and welcome the importance of the time, education, programs, and agenda in place addressing this life-threatening infection.  The C Diff Foundation advocates and supports the individuals and families suffering during and after being treated for a C. diff. infection.

Finally, the third verb that the C Diff Foundation and C diff Survivors Alliance Network propose is “to go.”  Here we are all challenged to do something big or small — with what we are able to do.  With the unity of members with volunteers with patients, families, and clinicians we can make a difference with enthusiasm and simplicity to get up and go.  We can do for others  today what we could not do for ourselves during our time of illnesses, during the long periods of isolation, during the losses, and during the pain and suffering.

As members of the C Diff Foundation we know that our enthusiasm  for our mission is the desire to bring awareness and promote C. difficile infection prevention, treatments, environmental safety and support worldwide.  We witness changes by the data and information being delivered within villages,  through major cities and in small communities — it is only by taking this path that we gain satisfaction knowing that the news delivered with enthusiasm “to promote, to heighten awareness and to go” with the members and volunteers in the C Diff Foundation and C diff Survivors Alliance Network creates positive results.

We are truly grateful for your continued dedication, efforts and support and thank you again for making this year’s November anniversary such a special occasion through the growth and advances made worldwide.   Let’s carry the mission into the New Year, carving new paths to witness the decline of newly diagnosed cases of Clostridium difficile (C.diff., C. difficile) infections and saving lives worldwide.

“None of us can do this alone ~ All of us can do this together.”

 

 

June 2017 Newsletter

JUNE 2017 – NEWSLETTER

 


5th Annual International C. diff. Awareness

Conference & Health EXPO Updates

Welcome to the 5th Annual International C.diff. Awareness Conference & Health EXPO  second update.  The Conference & Health EXPO begins on November 9th at 8:00 a.m. and concludes on November 10th at 3:00 p.m. There are over twenty guest speakers, leading topic experts, sharing up-to-date data with an audience of health care professionals from a variety of management levels and specialties, medical educators, medical students, and professionals with shared interests. The venue is the University of Nevada Las Vegas (UNLV) Thomas and Mack Center in conjunction with the Embassy Suites Convention Center where staff and event coordinators are working together to create this amazing event.  Embassy Suite Convention Center hotel accommodations are now at a “limited availability.”  Please utilize the hotel reservation portal available on the conference page
We are truly grateful for the following Corporations and Sponsors of this educational conference, also exhibiting.
An educational grant has been awarded to the C Diff Foundation by
Sanofi Pasteur USA.  It is through their continued support that this event is made possible:
DIAMOND SPONSOR
Synthetic Biologics
GOLD SPONSORS
Roche
Clorox Healthcare
Rebiotix
Nestle Health Science
Seres Therapeutics
Xenex
SILVER SPONSORS
Tru-D
Surfacide
SporeGen
EDM – Environmental Disinfection Management
ADDITIONAL EXHIBITORS
Contagion Live
Just Ask Where Concierge
Safety Net
www.cdiffradio.com
Live Broadcasts on Tuesdays at:   
10a PT,    11a MT,   12p CT,    1p ET 
June 6th :   Global Sepsis Alliance
June 13th:   Kristopher Maday, PA
June 20th:   Home Care and C. diff.
June 27th:   Advocating In Healthcare

Baking For C.diff. Awareness

Volunteer Patient Advocates, with the
C Diff Foundation Members,  were busy in the kitchens baking across the globe to support our mission and provide education at each event.
We kicked off the month long chain of events with a successful recipe to educate and advocate for
C. difficile infection awareness worldwide.  More than 700 brochures were shared at the bake sales meeting  the goal –  promoting C. diff. infection prevention, treatments, environmental safety and support across the globe during the month long campaign.  Thank You to everyone involved making this campaign a global success.

Save the Date

On September 14th a day to  Honor the Professionals Dedicated to Clostridium difficile Research and Development. Their Efforts Bring Forth New Concepts, New Theories, and the Progress Towards A Better Understanding – Pursuing Future Developments In Clostridium difficile           (a.k.a., C.diffiicle, C.diff.).
September 14th,   8:00 a.m. – 12:00 p.,m. ET
This free, live webinar by C.diff. Science, is to honor Professionals in the Science community, leading the way advancing C. difficile Infection Prevention, Treatments, and Environmental Safety Products worldwide  –  hosted by the C Diff Foundation –  a slate of industry leaders and medical researchers — from highly regarded health systems — share their journeys and efforts focused on Clostridium difficile research and development that will be appreciated by colleagues, fellow-researchers, and the scientific teams within organizations.
 
Visit cdiffscience.org To View the Guest Speakers, Presentation Topics.
Register For This One Day Educational Event and Don’t Forget To Share the News.
June  9     Scott Battles: C. diff. Q & A
June 15    Karen Factor,RD, Nutrition
June 19    Lisa Hurka-Covington, Anxiety
June 20    Roy Poole, CO  C. diff. Q & A
June 26    Dr.Oneto,MD  and
                 Dr.Feuerstadt,MD
                 C. diff. – The What,Where,How.
                   Sign up today
Where Support Is Just a Phone Call Away ♥ 

Support and information sessions are for everyone especially for —

  • Patients and their Families.
  • Clinicians,
  • C. diff. survivors continuing their recovery from a prolonged illness.
  • Patients working their way through any long-term wellness draining diagnosis.
Sessions are accessible from the USA and
57 Countries

Connect with others being treated for and recovering from a C.diff. Infection.

Ask questions, get advice & support.
Sign up FREE

www.cdifffoundation.org/support/

Treasure Island, FL Community EXPO Promoting

 C.diff. Awareness

It was a pleasure joining the local residents of Treasure Island, Florida on May 18th.  Educating and Advocating for C. difficile infection prevention, treatments, and environmental safety, a shared goal to witness a decline in newly diagnosed
C. diff. cases worldwide.  To view upcoming events of interest, please visit www.cdifffoundation.org/events-of-interest/
“None of us can do this alone, all of us can do this together.” 
C Diff Foundation
6931 ian Ct  #14
New Port Richey, FL 34653
(919) 201-1512
See what’s happening on our social sites:
C Diff Foundation | 6931 Ian Ct #14, New Port Richey, FL 34653
 

C difficile Study And Antibiotic Resistance; The Risks For Infection

Microscope - 5

C. diff Study Provides Insight Into Antibiotic Resistance and Risks for Infection

Exposure to specific antibiotics is linked to the development of certain strains of antibiotic-resistant C. difficile, one of the fastest growing bacteria superbugs, according to a new study published by Stuart Johnson, MD, of Loyola University Health System (LUHS), Loyola University Chicago Stritch School of Medicine (SSOM) and the Hines VA Medical Hospital.

“This discovery takes us one step closer to preventing C. diff and supports targeting specific antibiotics for antibiotic stewardship monitoring programs in the setting of high infection rates due to specific strains of C. diff,” said Dr. Johnson, the lead author, who reported the findings of the retrospective C. diff case control study in Antimicrobial Agents and Chemotherapy.

C. diff has been associated with multiple healthcare facility outbreaks and high national rates of C. difficile infection (CDI) since 2001 and now rivals Methicillin-resistant staphylococcus aureus (MRSA) in both frequency and severity.

Several infectious diseases, including MRSA and C. diff, have become resistant to antibiotics.

As a result, the medical community has deliberately reduced the routine practice of prescribing antibiotics for infectious diseases.

There currently is not a highly effective prevention method for C. diff.

“Antibiotic exposure is arguably the most important risk factor for C. difficile infection (CDI),” Johnson wrote.

“We know that antibiotics wipe out beneficial flora in the gut, making patients susceptible to a C. diff infection.

The other role of antibiotics highlighted in our study is that overuse of specific antibiotics may facilitate infection due to C. diff strains that are highly resistant to those antibiotics.”

Dr. Johnson and a team that included his longtime research partner, foremost C. diff expert Dale Gerding, MD, LUHS, SSOM, identified 143 patients with first episode CDI between 2005 and 2007 in one U.S. hospital at a time when increased CDI rates and severity were noted nation-wide.

Of those 103 patients, or 72 percent, were infected with the BI/NAP1/027 C. diff strain, which is highly resistant to fluoroquinolones and macrolides.

Most patients received multiple antibiotics within six weeks of being diagnosed with CDI. Fluoroquinolone and macrolide exposure was more frequent in patients with B1 strains, and the C. difficile bacteria recovered from the stool specimens of these BI-infected patients also showed high-level resistance to these antibiotics.

 

The article, “Fluoroquinolone and Macrolide Exposure Predict Clostridium difficile Infection with the Highly Fluoroquinolone-and Macrolide-Resistant Epidemic C. difficile Strain Bi/NAP1/027,” can be read online. Authors are Jeffrey T. Wieczorkiewicz, Bert K. Lopansri, Adam Cheknis, James R. Osmolski, David W. Hecht, Dale N. Gerding and Stuart Johnson.

Source: Loyola University Health System

 

To read article in its entirety click on the link below:

http://www.infectioncontroltoday.com/news/2016/02/c-diff-study-provides-insight-into-antibiotic-resistance-and-risks-for-infection.aspx

Frozen Yogurt Recipe To Make At Home

cdiffYogurt2

A message from the Registered Dietician 

With the warmer weather season upon us…..a cup of refreshing homemade frozen yogurt is not only enjoyable but is beneficial.

Natural probiotics should be ingested at the end of a meal; on a full stomach. This is due to the Ph balance of the G.I. system making it a desirable time for the live cultures to survive and be the most beneficial to the gastrointestinal system.

* Note: When taking Antibiotics it is best to wait two hours after ingesting probiotics to obtain the maximum benefits of the probiotics.
Frozen Yogurt Recipe : 6 ounces fresh or frozen berries stirred into 16 ounces vanilla yogurt then placed into a container recommended for freezing and enjoy.   For extra caloric value:  Add a 5 ounce package of shortbread cookies crushed well and then stir into the mixture before freezing.

C. difficile; A Preventable Infection Resulting In Personal Losses

worldaround

 

 

 

 

 

 

 

The C. difficile infection is a preventable infection, and more than 14,000 individuals die each year from or with the involvement of a C. difficile infection.

In eight hours time – it claims 13 individuals in America. 13 people will have died from a preventable infection.

While attending a “Raising C Diff Awareness” Conference you will listen to various presentations from world renown topic experts presenting on the many topics pertaining to  C. difficile prevention, treatments, and environmental safety. During the conference you will learn something important. Then the day after the conference we will all return to work and on that day we will remember those 13 individuals – we will remember the 14,000 + people nationwide.

Your skills, your passion is instrumental in saving their lives.

Remember:  None of us can do this alone…..all of us can do this TOGETHER!

Thank you and we look forward to meeting you at the

upcoming “Raising C Diff Awareness” conferences.

 
Nancy C Caralla
Executive Director of the C Diff Foundation

 

C. difficile Infection: EUCLID Study Reveals >39K Cases May Be Missed Yearly

* IN THE NEWS:  12 MAY 2014  *

 

EUCLID Study Reveals More Than 39,000 Cases of Clostridium difficile Infection  May Be Missed Each Year

 

Clostridium difficile is the major cause of infective, hospital-acquired diarrhoea in the developed world1

BARCELONA, SPAIN, 12 MAY 2014, PRNewswire/- The full set of data from EUCLID, the largest ever prevalence study of Clostridium difficile infection (CDI) across Europe, were presented today at the 24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). Data from 482 European hospitals reveal that in a single day, an average of 109 cases of CDI are missed due to a lack of clinical suspicion or inadequate laboratory testing, potentially leading to more than 39,000 missed cases in Europe each year.2

The study results show that incidence of CDI in Europe has increased (compared with previous studies) from 4.123 to 7.92 cases per 10,000 patient bed days between 2008 and 2012-13, respectively. Furthermore, the new data highlight that CDI PCR-ribotype 027, one of the most virulent PCR-ribotypes associated with CDI epidemics,4 is the most common in Europe.5 Countries with the highest rates of CDI testing had the lowest rates of this epidemic C. difficile strain.5

“Countries with increased awareness of CDI have probably been able to reduce outbreaks associated with the most virulent C. difficile strains by improving the early diagnosis of this usually healthcare associated infection” said Professor Mark Wilcox, Professor of Medical Microbiology, Leeds Teaching Hospitals & University of Leeds. “This study highlights that it is essential that we improve the implementation of CDI testing in hospitals, in order to tackle the issue of the increasing incidence of CDI across Europe.”

The EUropean multi-centre, prospective bi-annual point prevalence study of CLostridium difficile Infection in hospitalised patients with Diarrhoea (EUCLID) involved 482 hospitals from 20 European countries.

These full results compare data captured on two separate days, one in winter 2012/13 and one in summer 2013. On each of the assigned days, participating hospitals submitted all received unformed faecal samples to the respective EUCLID National Coordinating laboratories (NCLs). In total, 7,181 faecal samples were submitted by participating hospitals.2

Results of this study highlight marked recent shifts in CDI testing policy and methodology across Europe, resulting in improved testing policies and selection of laboratory methods.2 The data show that false-positive rates decreased between the two study days in those countries where testing procedures and methods had improved.2 Despite this, more than 50% of hospitals are still not using the most accurate testing procedure for CDI and more than one in five (21.8%) samples found to be positive for CDI at the NCL had not been tested at the local hospital level.2 In addition, the findings reveal that over half (52.1%) of hospitals in Europe only test for CDI at a physician’s request.2

“Guidelines recommend that hospitals test for CDI on all unformed stools when the cause of diarrhoea is not clear. However we are still seeing an issue with both a lack of clinical suspicion and lack of testing for CDI”, commented Professor Mark Wilcox. “CDI is a condition which causes considerable suffering for patients and a huge economic burden to hospitals across Europe. These results reveal that there is still more to be done in order to optimise CDI management and prevention.”

The EUCLID study is being coordinated out of the University of Leeds, UK, by Professor Mark Wilcox’s research group, with support from the EUCLID Core Group. The study was initiated and financially supported by Astellas Pharma Europe Ltd.

About Clostridium difficile Infection

CDI is a serious illness resulting from infection of the internal lining of the colon by C. difficile bacteria. The bacteria produce toxins that cause inflammation of the colon, diarrhoea and, in some cases, death.6 Patients typically develop CDI after the use of broad-spectrum antibiotics that disrupt normal bowel flora, allowing C. difficile bacteria to flourish.7 CDI is the leading cause of hospital acquired (nosocomial) diarrhoea in industrialised countries8 and the risk of CDI and disease recurrence is particularly high in patients aged 65 years and older.9 Recurrence of CDI occurs in up to 25% of patients within 30 days of initial treatment with current therapies.10,11,12 The ESCMID has identified recurrence as being the most important problem in the treatment of CDI.13

About Astellas Pharma Europe Ltd.

Astellas Pharma Europe Ltd., located in the UK, is the European Headquarters of Tokyo-based Astellas Pharma Inc. Astellas is a pharmaceutical company dedicated to improving the health of people around the world through the provision of innovative and reliable pharmaceuticals. As a global company, Astellas is committed to combining outstanding research and development (R&D) and marketing capabilities to continue to grow in the world pharmaceutical market. Astellas Pharma Europe Ltd. manages 21 affiliate offices located across Europe, the Middle East and Africa. In addition, the Company has an R&D site and three manufacturing plants in Europe. The company employs approximately 4,300 staff across these regions. For more information about Astellas Pharma Europe, please visit http://www.astellas.eu.

References

  1. Ananthakrishnan AN. Clostridium difficile infection: epidemiology, risk factors and management. Nat Rev Gastroenterol Hepatol 2011;8:17-26.
  2. Davies KA, et al. Second report from the EUropean, multi-centre, prospective bi-annual point prevalence study of Clostridium difficile infection in hospitalised patients with Diarrhoea (EUCLID) PO753. Presented at ECCMID 2014.
  3. Bauer MP et al. Clostridium difficile infection in Europe: a hospital-based survey. Lancet 2011; 377:63-73.
  4. Kuijper EJ, Coignard B, Tull P. Emergence of Clostridium difficile-associated disease in North America and Europe. Clin Microbiol Infect 2006;12 suppl 6:2–18.
  5. Davies KA. Increased diversity of C. difficile PCR-ribotypes across European countries and disparity of 027 prevalence; results of a European prevalence study of Clostridium difficile infection (EUCLID). Presented at ECCMID 2014.
  6. Poutanen SM, et al. Clostridium difficile-associated diarrhoea in adults. CMAJ 2004;171:51–8.
  7. Kelly CP, et al. Clostridium difficile infection. Ann Rev Med 1998;49:375–390.
  8. Crobach MJ, et al. European Society of Clinical Microbiology and Infectious Diseases (ESCMID): Data review and recommendations for diagnosing Clostridium difficile-infection (CDI). Clin Micro Infect 2009;15:1053–1066.
  9. Pepin J, et al. Increasing risk of relapse after treatment of Clostridium difficile colitis in Quebec, Canada. Clin Infect Dis 2005;40:1591–7.
  10. Bouza E, et al. Results of a phase III trial comparing tolevamer, vancomycin and metronidazole in patients with Clostridium difficile-associated diarrhoea. Clin Micro Infect 2008;14(suppl 7):S103-4.
  11. Lowy I, et al. Treatment with Monoclonal Antibodies against Clostridium difficile Toxins. N Engl J Med 2010;362;3:197-205.
  12. Louie TJ, et al. Fidaxomicin versus vancomycin for Clostridium difficile infection. N Engl J Med 2011;364:422–31.
  13. Bauer MP, et al. European Society of Clinical Microbiology and Infectious Disease (ESCMID): treatment guidance document for Clostridium difficile-infection (CDI). Clin Micro Infect 2009;15: 1067-79.

The EUCLID study is being coordinated out of the University of Leeds, UK, by Professor Mark Wilcox’s research group, with support from the EUCLID Core Group. The study was initiated and financially supported by Astellas Pharma Europe Ltd.

FDX/14/0017/EUf
Date of Prep: May 2014