The risk is particularly high for those with hematologic malignancies and those with recently diagnosed solid tumors
and distant metastasis (Emerg Infect Dis 2019;25:1683-1689).
“CDI is the leading cause of healthcare-associated infection,” said Mini Kamboj, MD, the chief medical epidemiologist of infection control at Memorial Sloan Kettering Cancer Center in New York City. “Older adults over the age of 65 are at a higher risk for developing CDI and related complications. Our study demonstrates that this risk in advanced age is further amplified by a cancer diagnosis.”
Dr. Kamboj and her colleagues conducted a retrospective cohort study using population-based Surveillance, Epidemiology, and End Results/Medicare–linked data to assess CDI occurrence during 2011. Medicare beneficiaries with and without cancer were included. For those with cancer, patients with solid (breast, colon, lung, prostate, and head and neck) and hematologic (lymphoma, myeloma, and leukemia) tumors diagnosed from 2006 to 2010 were included. All included participants were at least 66 years of age at the time of diagnosis. They also included patients at least 66 years of age at the start of 2011 with no history of cancer.
Of the 93,566 beneficiaries in the study, 2.6% were diagnosed with CDI during the study period. Of these, 2.8% of the patients with cancer had CDI, compared with 2.4% of the noncancer patients. The incidence of CDI also increased with age: from 1.9% among patients 66 to 69 years of age to 2.9% among patients at least 85 years of age.
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