Microbiome and Microbiota Basics

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We hear a lot of discussions and research in progress regarding the Microbiome ……

What is the Microbiome?  A microbiome is “the ecological community of commensal, symbiotic, and pathogenic microorganisms that literally share our body space.
Joshua Lederberg coined the term, arguing the importance of microorganisms inhabiting the human body in health and disease. Many scientific articles distinguish “microbiome” and “microbiota” to describe either the collective genomes of the microorganisms that reside in an environmental niche or the microorganisms themselves, respectively.However; by the original definitions these terms are largely synonymous.

The human body contains over 10 times more microbial cells than human cells, although the entire microbiome only weighs about 200 grams (7.1 oz), with some weight estimates ranging as high as 3 pounds (approximately 48 ounces or 1,400 grams).

it is regarded as a “newly discovered organ” since its existence was not generally recognized until the late 1990s and it is understood to have potentially overwhelming impact on human health – Modern techniques for sequencing DNA have enabled researchers to find the majority of these microbes, since the majority of them cannot be cultured in a lab using current techniques.

The human microbiome may have a significant role in auto-immune diseases (e.g., diabetes, rheumatoid arthritis, muscular dystrophy, multiple sclerosis, fibromyalgia, and perhaps some cancers).

It is ……the complete genetic content of all the microorganisms that typically inhabit a particular environment, especially a site on or in the human body, such as the skin or the gastrointestinal tract.


Sourece: Wikipedia