Pediatric Clostridium difficile Infection Surveillance Study By Dutch Researchers


Dutch study finds incidence of pediatric C diff stable

A study by Dutch researchers (Oct 21, 2016) finds that the incidence of pediatric Clostridium difficile infection (CDI) has been stable over the previous 6 years.

The surveillance study, published in Clinical Infectious Diseases, included all CDIs reported from May 2009 to May 2015 by 26 Dutch hospitals participating in a national sentinel surveillance study. Infected children were 2 and older. Investigators distinguished between healthcare-onset CDI (in which symptoms began in a hospital or long-term care facility) and community-onset CDI (when symptoms began at home).

Overall, 4,691 CDIs were included in the study, with a total of 135 pediatric CDIs (3%) being reported at 17 hospitals. The investigators did not observe an increase in the monthly number of reported pediatric CDIs during the study period. The median age of the children with CDI was 10 years.

Of the 135 pediatric CDI cases, 55% were community-onset, and 31% met the criteria for severe CDI. Although severe CDI was more likely to occur in children, it resulted in fewer complications than adult CDI. In contrast to adults, there was no CDI-related mortality. Pediatric CDI cases were more likely to occur in university hospitals than non-university hospitals.

The investigators also found that, of the 36 C difficile PCR ribotypes identified, ribotype 265 was most prevalent in children (15%) but rarely found in adults.

The authors note that the findings are in contrast to several studies in recent years that have shown an increase in the incidence of pediatric CDI in community settings and hospitals in the United States.
Oct 19 Clin Infect Dis abstract  


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