Tag Archives: University of Minnesota

The Power Of Microbes In Recurrent C.diff. Infection (CDI) 94%-96% Cure Rates

Microscope - 5

“Treating patients with recurrent C. difficile infection with microorganisms alone provides cure or reduction of symptoms at a rate many times higher than any drug or chemical that has ever been looked at. These cure rates of 94% and 96% are astronomical, and it is all due to the power of microbes, ” said Michael Sadowsky, PhD, Director of the BioTechnology Institute at the University of Minnesota, St. Paul, Minnesota.

“I think the future of medicine in the 21st century is to use the power of microbes to cure diseases.”

This new work, published in mBio, an open access journal of the American Society for Microbiology, has found which microbes are most effective in the fecal transplant procedure. The microbes from donor samples were purified and transplanted into patients to find which conferred the most benefit. The researchers used next-generation sequencing to assay the microbial populations of patients and donors.

Their findings surprised them; while they met expectations by curing around 90 percent of patients, some people who had received a placebo treatment, made up of their own fecal sample, were also cured. The researchers were able to determine that the patients cured by placebo already had some types of curative bacteria in their guts, strains that were boosted when they got the placebo.

“As opposed to what we thought, complete engraftment of microbiota is not required to cure a patient,” said Sadowsky.

“The study provides insight into which microorganisms are the most important for curing C. difficile and may allow clinicians to better tailor therapy, by improving donor material to facilitate a more rapid, effective, and lasting cure.”

Scientists can use this new data to optimize their treatments. “This paper provides us data with which microbes to supplement into our preparations,” Sadowsky concluded.

To read the article in its entirety click on the following link to be redirected:

https://www.labroots.com/trending/microbiology/4839/understanding-improving-fecal-microbiota-transplants?utm_content=buffer081c1&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

Fecal Transplant Pill Introduced

Clearly a true innovative treatment for the recurrence of C. diff.. During IDWeek 2013, taking place in San Francisco, California, Canadian authors presented the new study and first formal success of fecal transplant pills treating the recurrence of C. diff. infections.

Dr. Thomas Louie, an infectious disease expert from the University of Calgary, found a way to package donated stool into vitamin-sized capsules used to repopulate the intestines of C. diff sufferers with beneficial bacteria. Dr. Louie has treated 27 patients and none had a recurrence of C. diff, even though all of them had had at least four bouts of the infection, which can lead to severe disease or death.

Quoted from the article:
Fecal transplant experts at the University of Minnesota have had some success with freezing fresh stool, and some suggest that freeze-drying the organisms might be a way to preserve it for wider use. Dr. Cliff McDonald, a C. diff expert at the CDC, said Louie’s work represents further innovation in the potentially life-saving treatment for the infections. “The idea has been held by a few for a number of years, but no one else I am aware of is actually doing it this way other than Dr. Louie,” he said.

Dr. Colleen Kraft, who performs fecal transplants at the Emory University School of Medicine, agreed.
“This is clearly the future of fecal transplant therapy,” she told NBC News. “And there are many poised in the market to support this type of therapy and related synthetic bacteriotherapy. I do not see any drawbacks if it is indeed efficacious.”

To read this article in its entirety please click on the link below:

http://www.nbcnews.com/health/poop-pills-are-latest-way-cure-dangerous-c-diff-infections-8C11300066