Tag Archives: C difficile clinical study

C. diff. Spores and More Discuss Rebiotix: The Leader In Unlocking the Benefits of Microbiota Restoration Therapy (MRT) With Founder and CEO, Lee Jones

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C. diff. Spores and More,” Global Broadcasting Network – innovative and educational interactive healthcare talk radio program discusses

This Episode:       Rebiotix: The Leader in Unlocking the Benefits of Microbiota  Restoration Therapy (MRT)  “

With Our Guest:              Lee Jones, Founder and CEO, Rebiotix

Join us today on C. diff. Spores and More discuss Rebiotix
with Rebiotix Founder, CEO Lee Jones.  Listen in as we learn more about
the History, Company profile, the problems they are solving, and product information.  Lee will explain What is the microbiome? Their first product RBX 2660 – addressing C. diff, with the Rebiotix platform called MRT (Microbiota Restoration Therapy) and how  MRT is different
and much more.  

MORE ABOUT OUR GUEST:

Lee Jones, CEO and Founder of Rebiotix Inc., is an experienced medical technology executive and serial entrepreneur. With deep experience in the medical devices industry and in managing and advising academic scientists on commercialization efforts, Rebiotix marks her first foray into biotechnology. She is leading a fast-paced effort to develop a new way of treating disease through Microbiota Restoration Therapy (MRT). The company’s first MRT is a biologic drug targeted at recurrent Clostridium difficile infection.
Rebiotix Founder, President, CEO,  Privately held biotechnology company founded in 2011   Developing a new category of drugs to harness the human microbiome to treat disease; involves transplantation of live human-derived microbes; first target is recurrent Clostridium difficile infection, Led pioneering work with the US Food and Drug Administration to develop a new classification for the product – RBX2660 – completed Phase 2 clinical testing.

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C. diff. Spores and More ™“ Global Broadcasting Network spotlights world renowned topic experts, research scientists, healthcare professionals, organization representatives,C. diff. survivors, board members, and C Diff Foundation volunteers who are all creating positive changes in the C. diff. community worldwide.

Through their interviews, the C Diff Foundation mission will connect, educate, and empower many worldwide.

Questions received through the show page portal will be reviewed and addressed  by the show’s Medical Correspondent, Dr. Fred Zar, MD, FACP,  Dr. Fred Zar is a Professor of Clinical Medicine, Vice HeZarPhotoWebsiteTop (2)ad for Education in the Department of Medicine, and Program Director of the Internal Medicine Residency at the University of Illinois at Chicago.  Over the last two decades he has been a pioneer in the study of the treatment of
Clostridium difficile disease and the need to stratify patients by disease severity.

To access the C. diff. Spores and More program page and library, please click on the following link:    www.voiceamerica.com/show/2441/c-diff-spores-and-more

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Programming for C. diff. Spores and More ™  is made possible through our official  Sponsor;  Clorox Healthcare

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Dr Dale Gerding MD Has Retained The Chicago Corporation To Assist In Locating Exclusive Licensee for Patented Non-Toxigenic Clostridium difficile “NTCD” For Prevention and Treatment of C. diff. Infection

IN THE NEWS

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Dale Gerding, MD, an infectious diseases specialist, researcher, professor and hospital epidemiologist, and one of the leading international experts on Clostridium difficile (“C. diff”), has retained The Chicago Corporation to assist him in finding an exclusive licensee for his patented non-toxigenic Clostridium difficile (“NTCD”) technology for the prevention and treatment of Clostridium difficile infection. Dr. Gerding currently owns patents and all rights to the development, manufacturing, regulatory and clinical trial data for NTCD.

The lead pharmaceutical product, NTCD-M3, incorporating this technology has already completed Phase 1 and 2 Clinical Trials, has FDA Fast Track approval, and is expected to be eligible for Breakthrough Therapy Designation by the FDA for a Phase 3 Clinical Trial and to be eligible for Reference Product Exclusivity for 12 years for an approved biologics license application.  The exclusive licensee would be responsible for manufacturing, continuing development, obtaining pivotal trial regulatory approval in the US and Europe, marketing and selling of the pharmaceutical products. Phase 2 trial has shown that Dr. Gerding’s invention and treatment, NTCD-M3, is effective in significantly reducing the recurrence of C. difficile infection from 30 percent for placebo to 5 percent for the most favorable NTCD-M3 dosage.

CDC reports that C. diff, a highly infectious bacterium, is the most common microbial-cause of healthcare associated infections in the U.S. and can cause symptoms ranging from diarrhea to severe colitis to death, particularly in older patients. It occurs after use of antibiotic treatment and in the US affects over half million people a year including recurrences. It results in up to $5.9 billion per year in excess health care costs.  Reducing its occurrence is a national priority for the Centers for Medicare and Medicaid Services.

Dale Gerding, MD, MACP, FIDSA, FSHEA, is the Chief Medical Officer at a clinical stage biotechnology company and currently a Professor of Medicine in the Division of Infectious Diseases at Loyola University Chicago Stritch School of Medicine and Research Physician at Hines Veterans Administration Hospital.  He has been a Merit Review funded research investigator in the VA for over 35 years and is the author of over 300 peer-reviewed journal publications.

The Chicago Corporation is a middle-market investment banking firm that provides corporate finance services including merger and acquisition, capital raising and other financial advice to middle-market companies.

To read the article in its entirety please click on the link below:

http://www.prnewswire.com/news-releases/dale-gerding-md-seeks-licensee-for-non-toxigenic-clostridium-difficile-treatment-and-prevention-technology-300247170.html

Summit Therapeutics To Present Further Data Showing Superiority Of Its New Antibiotic At the 26th ECCMID Conference

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Summit Therapeutics is to present further data showing the superiority of its new antibiotic for hospital superbug C.diff. over the standard of care medicine.

The additional data on Summit’s ridinilazole versus vancomycin comes from the from the Phase 2 CoDIFy trial and will be heard at the 26th European Congress of Clinical Microbiology and Infectious Diseases Conference  (ECCMID).

(ECCMID 2016  Will be hosted in Amsterdam from 9 – 12 April )

Taking the antibiotic ridinilazole resulted in a marked reduction in rates of C. diff. (CDI) recurrence as compared to vancomycin (14.3% versus 34.8%) the drug discovery firm will say.

This result comes on top of t previously reported statistical superiority in ‘sustained clinical response’ rates of ridinilazole over vancomycin (66.7% compared to 42.4%) for treating the disease.

Sustained clinical response is defined as clinical cure at the end of treatment and no recurrence of the condition in 30 days after therapy.

C. diff is a serious threat in hospitals and care homes and there are between 450000 and 700000 cases in the US annually.

Recurrence is a key problem as repeat episodes are typically more severe and associated with an increase in mortality rates and healthcare costs.

 

 

To read the total article, click on the following link:

http://www.menafn.com/1094678222/Summit-Therapeutics-to-present-further-data-showing-ridinilazoles-superiority

*Please note – The C Diff Foundation does not endorse this product or any product and this posting is strictly for informational purposes only.

 

 

 

C. diff. Spores and More Global Broadcasting Network Welcome Guests; Dr. David Cook, Ph.D., and Dr. Michele Trucksis, Ph.D., M.D. Of Seres Therapeutics, Inc.

“Ecobiotics: A Novel Approach to Recurrent C. difficile infections”

Tuesday, February 23rd — Live Broadcast

PODCAST IS NOW AVAILABLE, PLEASE CLICK ON THE SERES THERAPEUTICS LOGO BELOW

10 a.m. Pacific Time,,   11 a.m. Mountain Time,
12 p.m. Central Time,    1 p.m. Eastern Time

We invite you to  listen to the live broadcast and archived programs by clicking on the
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This episode introduces Seres Therapeutics, a leading microbiome therapeutics company, which recently published in the Journal of Infectious Diseases positive results from an open-label Phase 1b/2 study of SER-109 for the treatment of patients with recurrent
C. difficile infections (CDI).  Seres Therapeutics is creating a new class of medicines to treat diseases resulting from functional deficiencies in the microbiome, a condition known as dysbiosis.

TO LISTEN TO THIS EPISODE – PLEASE CLICK ON THE SERES THERAPEUTICS LOGO BELOW

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New insights into the human microbiome are fundamentally reshaping how we understand and treat a wide range of diseases, creating new possibilities for patients not served by current therapeutic approaches. Ecobiotics are ecological compositions of beneficial organisms that are designed to reestablish a healthy microbiome. The discovery efforts at Seres Therapeutics currently span metabolic, inflammatory, and infectious diseases.

Join Guests;  
Dr. David Cook, Ph.D., Executive Vice President of R&D and Chief Scientific Officer
And
Dr. Michele (Shelley) Trucksis, Ph.D., M.D., Executive Vice President and Chief Medical Officer

As we discuss the microbiome, CDI, clinical studies SER-109, Probiotics, ECOSPOR, and much more

 

C. diff. Spores and More™  Global Broadcasting Network –  producing educational programs dedicated to  C. difficile Infections and more —  brought to you by VoiceAmerica and sponsored by Clorox Healthcare

 

Seres Therapeutics Disclaimer:
“This interview will include forward-looking statements on Seres Therapeutics’ current expectations and projections about future events. These statements are based upon current beliefs, expectations and assumptions, and are subject to a number of important risks and uncertainties, including those set forth in Seres Therapeutics’ filings with the SEC, many of which are difficult to predict. Actual results may differ materially from such statements. The information included in this interview is provided only as of the date of this interview, and Seres Therapeutics undertakes no obligation to update any forward-looking statements stated in this interview on account of new information, future events, or otherwise, except as required by law. Seres Therapeutics has provided financial support to the C Diff Foundation.”