* In the news *
http://www.foxnews.com/health/2014/08/26/grossed-out-by-fecal-transplants-now-there-pill-instead/
Fecal microbiota transplants (FMTs) are exactly what they sound like. They involve taking feces from a healthy person and putting them into the body of a sick patient to strengthen the community of bacteria that live in the patient’s gut.
FMTs are very effective at curing stubborn infections with Clostridium difficile (C. diff). The deadly bacteria cause 500,000 illnesses and 14,000 deaths each year in the United States. Small studies have shown that FMTs can cure about 90 percent of serious C. diff infections. They have been so successful that scientists are testing the transplants for other conditions, such as irritable bowel syndrome.
However, FMTs have their downsides. They’re invasive, they can spread disease, and — let’s face it — they’re gross.
What if patients could get the benefits of an FMT without the “ick factor”? A team led by researchers at the Mayo Clinic has developed a delayed-release pill, dubbed SER-109. Research suggests that it may be just as effective as a traditional transplant.
How Does the Pill Work?
In a trial of 15 patients with multiple flare-ups of C. diff infection, SER-109 cured all 15 within eight weeks. At the end of the trial, none of the patients had diarrhea, the hallmark of C. diff infection. All tested negative for the bacteria.
“The results of the study were not surprising and we were expecting a high cure rate,” lead study author Dr. Sahil Khanna of the Mayo Clinic told Healthline. “Previous studies involving conventional fecal transplant from the upper gut have demonstrated good success rates.”
Doctors think that giving patients large doses of antibiotics triggers C. diff infections. Antibiotics destroy the normal, helpful gut bacteria that help the body fight harmful microbes like C. diff. To cure the infection, doctors must reintroduce the good bacteria the patient has lost.
The pill required far fewer live bacteria than a traditional transplant. Even with fewer bacteria to re-seed the patients’ guts, the researchers confirmed that the pill quickly restored bacterial diversity.
Khanna, a gastroenterologist, said that the delayed-release capsules allowed the bacteria to survive the acidity and enzymes in the upper gastrointestinal tract and make it into the patient’s lower gut.
*To read article in its’ entirety click on the link above*
* In The News *
SeraCare Life Sciences, a provider of high-quality biological materials that help optimize diagnostic performance, reliability and repeatability across the IVD lifecycle, today announced the launch of its new ACCURUN® 501 C. difficile Control – the company’s first molecular control product targeting hospital acquired infections.
ACCURUN 501 C. difficile Control is formulated for use with in vitro diagnostic tests that detect C. difficile DNA in human stool samples. Manufactured from cultured Clostridium bacteria of four different strains or species delivered in a set of four vials, the bacteria are inactivated and in a human synthetic stool matrix. The control is ready-to-use in assays that detect C. difficile DNA with any transport system.
“Hospital acquired infection assays present unique sample challenges which require dependable, whole cell controls. Our new ACCURUN® 501 product is a full process control that is intended to not only estimate laboratory testing performance but also immediately detect analytical errors and monitor the entire testing process. As a result, our customers have greater confidence in fulfilling their QC requirements,” says Christopher Long, Product Manager at SeraCare.
SeraCare’s new ACCURUN® 501 product is available immediately in the U.S. and internationally. For more information, contact SeraCare Customer Service at 1-800-676-1881 or visit www.seracare.com.
About SeraCare Life Sciences, Inc.
SeraCare works with diagnostics researchers, IVD manufacturers, and clinical laboratories to shape the future of medical diagnostics. Our innovative portfolio includes ACCURUN® quality controls, research panels, KPL™ antibodies and immunoassay reagents, SeraCon™ processed plasma, specialty human blood products, and Complete BioCollections™ materials. SeraCare helps bridge the gap between today’s diagnostic solutions and tomorrow’s emerging technologies for molecular diagnostics, next generation sequencing and companion diagnostics.
Company Contact: |
Agency Contact: |
Marsha Ann Marsh |
Shannon Meirzon |
SeraCare Life Sciences, Inc. |
Pyxis Communications |
508.244.6400 ext. 6106 |
203.550.5978 |
C.diff infection treated in home environment
Laundry:
While combating C. diff at home, it is recommended that soiled linens be handled as little as possible to prevent microbial contamination of persons handling the linen. Heavily soiled linens should be laundered separately and not with other clothing or other linens. Satisfactory Laundering has been achieved in “hot” water temperatures cycles in home washers while utilizing chlorine bleach (amount varies with manufacturer and water capacity in each washer) and laundry soap.
Hand-washing with soap and warm water over 20 seconds, scrubbing between fingers, and tops of hands, rinsing with fingers pointed downward, using a dry, clean towel to dry both hands and a dry towel to turn off the sink faucets. This hand-washing process demonstrates the greatest efficiency in removing Clostridium difficile (C Diff) spores and should be performed preferentially over the use of alcohol-based hand rubs when contact with C Diff is suspected or likely. The recommended length of time to wash hands is a minimum of 20 to 30 seconds. Singing one rendition of Happy Birthday usually suffices the time suggested to achieve good hand-washing results.
* 70% isopropyl showed NO inactivation of C. difficile spores at exposure times of 5m, 15m, and 30m.
Cleaning a Home Environment:
What needs to be cleaned at home using EPA approved germicide for routine cleaning? All hard surfaces, which include the bedside commode (if applicable), bed-rails (if applicable), All Bathroom sinks, floors, tub/showers, toilets, doorknobs, light switch plates, shower doors. Frequently touched or high-touch surfaces including computer touch-pads, monitor cables, monitors, Kitchen appliances (i.e., Refrigerator handles, oven handles) sinks, counter-tops, floors and any/all medical equipment being utilized (i.e., walker, wheelchair, IV poles/pumps).
Clean all items that are shared between individuals (i.e., glucose meters, thermometers, b/p cuffs, stethoscopes). *It is best to use disposal wipes, paper towels, or cleaning clothes that can be washed in hot bleach water after cleaning, sponges are not recommended. The dirty cloth should not return to a clean bucket of solution and buckets/containers should be washed and disinfected after each use.
Home Restrooms: To also help prevent spreading C. diff. spores and to prevent reinfection: Restrooms - remove fabric shower curtains - replace with a plain plastic/vinyl shower liner one that will be able to be cleaned with a bleach product. Remove towels hanging on hooks, or stacked near the commode. Store toothbrushes, personal grooming items, and towels in a cabinet, linen closet, in zip-lock plastic bags, or under the vanity sink is a safer location. Remove bath mat/rug or launder daily in hot water with bleach added (color fabrics may fade due to bleach - read manufacturer labels). Cleaning with disposable towels is beneficial. CDC Recommendation is Utilizing Bleach/Water 1:10 ratio: 1 cup of Bleach + 9 cups of water made fresh daily and keeping surfaces wet with solution for ten minutes. Or there is the option to purchase EPA Registered product such as Clorox (TM) Germicidal Solution or wipes to clean hard non-porous surfaces and leaving surfaces wet for up to five minutes to kill C. diff. spores. Environmental safety is a sure way to prevent spreading the C. diff. spores and/or reinfecting the patient
Hospital Visits:
While visiting a loved one in the hospital, wearing a gown and gloves is very important. Clostridium difficile (C diff) spores will spread throughout areas easily and by complying with hospital policies you will keep your family member, friend, yourself, and others safe. Please wash your hands after removing gloves before leaving the room you are visiting, and please wash your hands upon re-entering before new gloves and gown are worn.
ALL “TOUCHABLE (HAND CONTACT)” SURFACES SHOULD BE WIPED
with cleaning agent containing Chlorine Bleach. The CDC cleaning ratio 1:10 solution; 1 cup bleach to 9 cups of water and used on non-porous surfaces over ten minutes and mixed fresh daily for effective cleaning solution OR with a EPA Registered Sporicide/Disinfectant (i.e., Steriplex SD, Clorox Germicidal).
Question: Do Clorox® Disinfecting Wipes contain bleach? NO
Clorox® Disinfecting Wipes, purchased at local markets, are made with a bleach-free formula that’s available in Fresh Scent, Lemon Fresh, Kitchen and Lavender scents so they leave a light, clean scent every time you wipe off a surface. * The “Disinfecting” wipes by Clorox will NOT kill C Diff Spores *
The Clorox Germicidal Wipes and Solution DO have the EPA Registered C Diff Kill.
Clorox Solution has been located and sold through Lowe’s Home Improvement Centers. Check with local stores for this product.
What do I need to do when I go home from the hospital?
Once you are back at home, you can return to your normal daily routine.
Often, the diarrhea will be better or completely gone before returning to home. This makes giving
C. diff to other people much less likely. There are a few things you should do, however, to lower the
chances of developing C. diff infection again or of spreading it to others.
• If you are given a prescription to treat C. diff, take the medicine
exactly as prescribed by your doctor and pharmacist. Do not take half-doses or stop before you run out.
• Hand-washing remains #1 prevention: Take frequent 20 second hand-washing breaks during the day, especially after visiting the bathroom, before and after preparing food, after visiting stores, after visiting the gym, before and after eating, after traveling on public transportation, and often.
Cleaning with a chlorine bleach cleanser will help kill C Diff spores in the home environment.
* If any C. diff symptoms (diarrhea, fever, abdominal cramping) are noticed, please contact the primary physician, healthcare professional and/or seek medical attention at the local clinic/emergency department for assessment and C. difficile stool testing.
http://www.theukprobioticsconference2015.co.uk/
To access the website - please click on the link above.
The following information is directly from the UKPC website:
The UK Probiotics Conference 2015. Here you will find everything you need to know about the conference, the first of its kind to be held in the UK. If you are considering attending this conference, you will already know that the field of probiotics has now expanded beyond all expectations over the last two decades. Ever-growing clinical and field data suggesting beneficial effects of probiotics in humans and animals has lead to the increase of related products on the market, from simple health food supplements to established brands. Underlying this is the growing awareness of the link between gut health and the intestinal flora.
The conference will be held over 2.5 days and will comprise of 6 themed sessions of 20-30 minute talks, a poster session, networking breaks, a trade stand exhibition, meals, social events and entertainment. Please refer to the Full Schedule for more detail.
We are grouping talks around the following themes:
If you are interested in submitting a request for a talk, please contact Professor Simon Cutting, as soon as possible.