Tag Archives: What is Clostridioides difficile?

Clostridioides diffiicle Thrives In an Inflammed Environement ….Research Study From North Carolina State University

Clostridioides difficile thrives in an inflamed environment by generating toxins that support prolonged infection, according to a study from North Carolina State University.

The study, published in Nature Communications, showed how C. diff produces toxins that cause inflammation, eliminating competing bacteria and releasing peptides and amino acids that support the growth of C. diff.

C. diff thrives when other microbes in the gut are absent – which is why it is more prevalent following antibiotic therapy,” corresponding author Casey Theriot, Ph.D., associate professor of infectious disease at North Carolina State University, said. “But when colonizing the gut,
C. diff. also produces two large toxins, TcdA and TcdB, which cause inflammation. We wanted to know if these inflammation-causing toxins actually give C. diff a survival benefit – whether the pathogen can exploit an inflamed environment in order to thrive.”

Investigators examined two variants of C. diff in vitro and in an antibiotic-treated mouse model. The variants included a wild type C. diff that produces toxins and a genetically modified variant that does not. They found that the wild type C. diff, associated with toxin production, generated more inflammation and tissue damage than the mutant.

To read the article in its entirety, please click on the following link to be redirected:

https://www.contagionlive.com/view/clostridioides-difficile-thrives-in-inflamed-environment

Investigators also found changes in the expression of metabolic genes, with C. diff in the inflamed environment expressing more genes related to carbohydrate and amino acid metabolism that sustains growth.

C. diff’s toxins damage the cells that line the gut,” Theriot said. “These cells contain collagen, which is made up of amino acids and peptides. When collagen is degraded by toxins,
C. diff responds by turning on expression of genes that can use these amino acids for growth.”

Inflammation provided a second benefit to C. diff by creating an inhospitable environment for other bacteria that compete for nutrients. Bacteroidaceae were present in control groups that weren’t infected with toxin-producing C. diff, which was consistent with previous studies that found negative associations between C. diff and Bacteroidaceae.

“I always found it interesting that C. diff causes such intense inflammation,” first author Josh Fletcher, Ph.D., a former postdoctoral researcher at North Carolina State University, said. “Our research shows that this inflammation may contribute to the persistence of C. diff in the gut environment, prolonging infection.”

C. diff is the most significant cause of hospital-acquired diarrhea, causing more than 223,900 infections and 12,800 deaths in the US in 2017, according to a recent report.

The disease has two phases, a spore phase, and vegetative phase. Toxins are released during the vegetative phase, causing diarrhea and other symptoms. But the pathogen is often transmitted during the spore phase, during which it is hardy and isn’t susceptible to gastric acids and alcohol-based hand sanitizer, experts explained during a recent discussion of the disease.

Risks for infection include exposure to C. diff spores and antibiotic use. An investigational drug to prevent the disruption of the gut microbiota by antibiotics is among the most recent developments in the fight against a C diff. infection.

 

World Patient Safety Day 2020

World Patient Safety Day, is an initiative by the World Health Organisation to raise awareness of the need to continuously improve patient safety, building on the foundations of a safer culture and safer systems.

World Patient Safety Day 2020 will bring together health workers, patients, families, caregivers, communities, health care leaders and policy-makers, all showing commitment to health worker safety and patient safety. Health workers include all people engaged in actions whose primary intent is to enhance health. The year 2020 has been designated as the International Year of the Nurse and Midwife 

‘Safe health workers, Safe patients’ 

Members of the C Diff Foundation recognize the importance of this annual WHO “World Patient Safety Day” campaign and we ask fellow patients, health workers, health care leaders, patients, and healthcare professionals to actively participate and share this information with others.

Share using any of the following hashtags: #PatientSafety #WorldPatientSafetyDay #HealthWorker 

Thursday, September 17th is World Patient Safety Day. No one should be harmed in health care. And yet, every day, thousands of patients suffer avoidable harm while receiving care. The ongoing COVID-19 pandemic has exerted unprecedented pressure on health systems and health workers. An alarming number of health workers have also been harmed while responding to the COVID-19 pandemic. Safety of health workers has a significant impact on the safety of patients In view of this, the theme of World Patient Safety Day this year is Health Worker Safety: A Priority for Patient Safety. If you or a loved one are a patient, be actively involved in your own care. Enhance your knowledge about safety in health care and raise safety concerns with your health providers. Ask questions to be aware of your health condition and treatment. Speak up for the safety of your care as well as the safety of health workers!  

The 4th Annual Global C. diff. Awareness 2K Walks Go Virtual on September 11 and 12

The 4th Annual Global C.diff. Awareness 2K Walks Will Now Be VIRTUAL!

                   Join Us On……………….

Friday, September 11th – UK

Dr. Clokie, UK Walk Event Coordinator, will be hosting the VIRTUAL Walk in Leicester on September 11th as the UK is also under strict guidelines to slow the spread of the COVID-19 virus. 

  • The Leicester VIRTUAL Walk Will Begin at 10:00 a.m. – 11:00 a.m. – UK

  • VIRTUAL Entertainment Will Begin at 10:00 a.m. UK For the Children!

Saturday, September 12th –  USA

  • The VIRTUAL Walks Will Begin at 9:00 a.m. through 12:00 p.m. EDT

  • VIRTUAL Entertainment Will Begin at 9:00 a.m. EDT For the Children!

All Registered Awareness Walkers Will Receive a T-Shirt, Giveaways, and More via: United States Postal Service To the Address Provided at the Time Of Registration.

To Learn More About the Global C. diff. Awareness Walk Event and How You Can Register, Please Click On the Green Button Below……………..

 

 

 

We are truly grateful for your efforts, support and participation
of the Annual Walk events and we look forward to virtually walking with you in September!

“None of us can do this alone ~ All of us can do this together!”
~ C Diff Foundation

WEBINAR: Improving Care Transitions in Clostridioides difficile Infection November 14th, 2019 at 2:00 p.m. EST

WEBINAR

Improving Care Transitions in Clostridioides Difficile Infection

Thursday, November 14, 2019 at 2:00pm Eastern/11:00am Pacific

Intended Audience: Physicians, Nurse Practitioners, Physician Assistants, Nurses, Pharmacists and Case Managers

 Overview: With advances in Clostridioides difficile infection (CDI) treatment and recurrence prevention, and recently updated IDSA/SHEA guidelines, remarkable potential exists to improve CDI patient outcomes through effective interventions at critical transition points.

Join CDI experts Sahil Khanna, MD, MBBS, and Kevin Garey, PharmD, MS, FASHP, for an interactive webinar highlighting core concepts and strategies from the CDI Transitions of Care (TOC) Pathway. The CDI TOC Pathway was developed in partnership with the National Transitions of Care Coalition (NTOCC) to arm system leaders and CDI care teams with essential interventions and tools to ensure safe and effective TOCs for patients with CDI across care settings.

Agenda:

  1. Overview of the Clostridioides difficile infection (CDI) Transitions of Care Pathway
  2. How Do Ineffective Care Transitions Impact Patients with CDI?

III. Assessing CDI Risk and Implementing Diagnostic Stewardship

  1. Advances in the Treatment of Primary and Recurrent CDI
  2. Engaging CDI Patients and Caregivers in Effective and Safe Care Transitions

Expert Faculty:

Sahil Khanna, MBBS

Kevin W Garey, PharmD, MS, FASHP

Michael R Stinchon, Jr, RPH

 Offering 1.0 hour of ACCME, AAPA, AANP, ACPE, ANCC, and CCM credit.

Click on the graphic below to be directed to the webinar on

November 14th at 2:00  EST

 

 

 

 

 

 

Supporter statement: This activity is provided by PRIME Education. There is no fee to participate. This activity is supported by an educational grant from Merck & Co. Inc.