Tag Archives: C. diff. prevention

Infectious Disease Research Finds the Laundering of Removable Bed Barriers More Effective at Reducing Hospital-Acquired Infections Keeping Patients Safe

Infectious disease research highlights that laundering removable bed barriers is more effective at reducing hospital-acquired infections and keeping patients safe

A new peer-reviewed study published today in Sage Journals’ Infectious Disease Research and Treatment publication, found that cleaning and disinfecting mattresses by using removable, launderable bed barriers is more effective at eliminating bacteria that cause C. diff, MRSA, and E.coli than manual processes using chemical disinfectants. These findings indicate a new, much-needed industry best practice that hospitals must adopt to keep patients safe – especially in today’s COVID-19 reality as more patients begin to re-enter hospitals and resume elective procedures.

Most hospitals currently conduct a manual one-step process of cleaning hospital beds and mattresses, despite being off-label use of the disinfectant and the manufacturer’s multi-step instructions for cleaning and disinfection. Studies have also shown that mattresses, which are difficult to disinfect, contribute to the high rates of hospital-acquired infections (HAIs) in the United States. These concerns prompted ECRI to cite mattress contamination as one of its top health hazards in both 2018 and 2019.

“We evaluated the effectiveness of the commercial laundry process under extreme test conditions, using high concentrations of soilage, blood, and urine. Laundering the removable bed barriers eliminated every major organism that contributes to HAIs—when the fabric was tested both at the beginning and end of life of the barrier,” said Edmond Hooker, MD, DrPH, an epidemiologist and practicing physician who co-authored the study, “The findings are both significant and timely as hospitals grapple with growing concerns about patient safety and how to prevent the spread of COVID-19 and other diseases. The time is now to take action and protect patients with this evidenced-based approach to cleaning and disinfecting.”

The commercial laundry process detailed in the study provides detergent, bleach, agitation, and repeatability. These elements allow bacteria and spores to be physically separated from the barrier surface. The chlorine works to kill residual organisms. Multiple rinse cycles allow the microorganisms to be removed from the washing machine.

“The current state of cleaning and disinfecting beds and mattresses is dangerous because it can leave residual bacteria that can be transmitted from patient to patient. However, laundering removable bed barriers provides an alternative. It eliminates issues with insufficient removal of pathogens from the patient surface, ” said Ardis Hoven, MD, Professor of Medicine at the University of Kentucky and an Infectious Disease consultant to the Kentucky Department for Public Health. “Unlike the commonly used manual process, it exceeded FDA guidance on this type of device. Hospital administrators must translate this new knowledge into action to protect the patients and families they serve.”

Trinity Guardion, the maker of the Soteria Bed Barrier – a removable and launderable bed barrier – sponsored the study. Dr. Hooker is a professor at Xavier University’s Department of Healthcare Administration and associate professor at the University of Cincinnati Medical Center. To view the full study results, please visit the publication website.

 

To read the publication in its entirety please visit

www.trinityguardion.com

 

Clorox Healthcare® VersaSure™ Cleaner Disinfectant Wipes Introduced

Patented alcohol-free quat technology with the versatility to use throughout healthcare settings with broad-spectrum disinfection

 

 

Clorox Healthcare is proud to announce the latest addition to its industry-leading portfolio of healthcare disinfectants: new Clorox Healthcare® VersaSureCleaner Disinfectant Wipes, an innovative, alcohol-free quat solution versatile enough to use on common healthcare surfaces with the assurance of broad-spectrum disinfection.

Clorox Healthcare® VersaSureCleaner Disinfectant Wipes are Environmental Protection Agency (EPA) registered to kill 44 pathogens, including bacteria, viruses and fungi, in two minutes or less. The unique, low odor, low residue formula features patented technology that enhances quat activity on surfaces to deliver broader efficacy and faster kill times without co-actives. The result is a versatile, one-step cleaner disinfectant wipe with the speed and efficacy healthcare facilities rely on and superior aesthetics, wetness and cleaning power needed for convenient, compliant use facility-wide.

Clorox Healthcare® VersaSureCleaner Disinfectant Wipes’ innovative new formula provides:

  • Speed and Strength Against Key Pathogens: VersaSure is EPA-registered to kill 44 microorganisms, including 14 multi-drug resistant pathogens, in two minutes or less. VersaSure kills influenza viruses, respiratory syncytial virus (RSV), measles, mumps and other viruses in 30 seconds1 and kills bacteria and fungi, including methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin resistant Enterococcus faecalis (VRE), Escherichia coli (E. coli), salmonella, mycobacterium bovis (TB) and Candida albicans, in two minutes.
  • Excellent Aesthetics and Cleaning Power: Patented alcohol-free quat technology and innovative wipe design combine to provide excellent aesthetics, wetness and cleaning power. The low residue formula is designed for superior staff and patient comfort with no harsh chemical fumes or odors. Durable, low-linting wipes are textured for greater strength. Excellent wetness provides greater surface coverage compared with competitor quat and quat-alcohol disinfectant wipes and assurance that treated surfaces will remain wet for the full contact time.
  • Convenient, Compatible Use: VersaSure wipes are ready-to-use, fast acting and compatible with a broad range of hard, non-porous surfaces found in healthcare settings. A variety of sizes, including multipurpose wipes in 85 and 150 count canisters and 30 count flat packs, and terminal wipes for everyday cleaning and disinfecting of large spaces, available in 110 count buckets and refill pouches, makes VersaSure convenient for both nurses and environmental services teams to use facility-wide.

“Not all disinfectants are created equal and many don’t have the optimal balance of attributes to meet users’ needs. For example, a conventional quat or alcohol-based product might offer good compatibility, but have limited kill claims or evaporate from surfaces before meeting the required contact time,” says Brian Thompson, department manager – R&D, Clorox Healthcare. “We believe healthcare facilities shouldn’t have to make those trade-offs and with VersaSure, they don’t. Our R&D teams refused to make compromises between efficacy, aesthetics, wetness and cleaning power, and today we are excited to offer a one-step, ‘use everywhere’ wipe with broad-spectrum efficacy healthcare facilities can trust.”

Building the Industry’s Most Innovative, Comprehensive Portfolio of Disinfecting Solutions

In the fight against infections, today’s healthcare facilities need proven solutions to kill a broad range of pathogens, from seasonal threats like influenza and deadly pathogens like Clostridium difficile (C. difficile), to community-associated MRSA and new threats posed by emerging viral pathogens. Clorox Healthcare offers the industry’s most robust portfolio of EPA-registered surface disinfectants in addition to advanced UV technology, as well as cleaning and odor removal products to provide healthcare facilities, nurses and EVS professionals with a comprehensive portfolio of best-in-class solutions to help reduce the risk of infections and keep patients, staff, visitors and the broader community safe.

Clorox Healthcare understands that safeguarding healthcare environments requires advanced and evolving solutions. VersaSure joins products like Clorox Healthcare® Fuzion Cleaner Disinfectant, a new type of bleach that combines disinfecting efficacy against tough-to-kill pathogens like C. difficile spores with broad surface compatibility,

Clorox Healthcare® Bleach Germicidal Wipes and Clorox Healthcare® Hydrogen Peroxide Cleaner Disinfectants in a class of ready-to-use disinfectants that are tough on pathogens and optimized for surface compatibility, aesthetics, ease-of-use and patient and staff comfort to enable broad use, promote compliance and enhance safety facility-wide.

“At Clorox Healthcare, we are constantly innovating and working to expand the depth and breadth of our industry-leading portfolio, both by pushing the envelope with new product development and constantly striving for improvement to ensure that the mainstay surface disinfectants healthcare facilities depend on continue to meet the highest standards of efficacy and evolving needs of real-world healthcare environments,” says Lynda Lurie, director – marketing, Clorox Healthcare. “The expansion of our portfolio with the launch of VersaSure, brings us one step closer to our goal of removing the environment from the infection prevention equation.”

About Clorox Healthcare
Building on a century-long legacy in cleaning and disinfecting, Clorox Healthcare offers a wide range of products to help stop the spread of infection in healthcare facilities. From comprehensive surface disinfection to advanced ultraviolet technology, we are committed to providing efficacious solutions to the healthcare community. For more information, visit www.CloroxHealthcare.com or follow @CloroxHealth on Twitter.

1Kills rotavirus in two minutes.

 

Clorox Healthcare logo (PRNewsFoto/Clorox Professional Products Co.)

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SOURCE Clorox Healthcare

Read more at https://www.thecloroxcompany.com/release/#tHkDJjKXBYteXfXg.99

Study Show 9% Fewer Antibiotics Prescribed

The use of antibiotics among Americans with commercial health insurance has decreased during the past several years, according to a new analysis that nevertheless
shows lingering variations for different ages and in different parts of the country.

The study released provides the latest evidence of how doctors and patients have begun to heed warnings that excessive antibiotic use breeds dangerous drug resistance and “superbug” bacteria.

The analysis is based on 173 million insurance claims from people under age 65 with Blue Cross Blue Shield coverage
who filled prescriptions
between 2010 and 2016.

 

It is a sequel of sorts to research by the federal Centers for Disease Control and Prevention, which found a smaller decline and comparable age and geographic variations.

The CDC reported a 5 percent decrease overall between 2011 and 2014 in antibiotic prescriptions written in outpatient settings such as doctors’ offices, clinics and hospital emergency rooms.

The study by the Blue Cross Blue Shield Association found that 9 percent fewer antibiotics prescribed in outpatient settings were filled in 2016, compared with 2010.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

The Blue Cross Blue Shield Study:

https://www.bcbs.com/the-health-of-america/reports/antibiotic-prescription-rates-declining-in-the-US?utm_source=social&utm_medium=linkedin&utm_content=&utm_campaign=hoa-antibiotics

 

To read more of this article please click on the link provided below:

https://www.washingtonpost.com/news/to-your-health/wp/2017/08/24/fewer-antibiotic-prescriptions-are-being-filled-a-new-analysis-finds/?utm_term=.d30b61b8fae7

SYN-004 (ribaxamase) For C. difficile Prevention Advances; U.S. Food and Drug Administration (FDA) Has Granted A Breakthrough Therapy Designation

On May 11, 2017 Synthetic Biologics, Inc. a late-stage clinical company developing therapeutics that preserve the microbiome to protect and restore the health of patients, announced that the U.S. Food and Drug Administration (FDA) has granted a Breakthrough Therapy Designation for SYN-004 (ribaxamase) for the prevention of Clostridium difficile infection.

SYN-004 (ribaxamase) is the Company’s first-in-class oral enzyme designed to protect the gut microbiome from disruption caused by certain intravenous (IV) beta-lactam antibiotics.

The Breakthrough Therapy Designation is based on data from the successful Phase 2b clinical trial of ribaxamase, which met its primary endpoint of significantly reducing CDI. FDA Breakthrough Therapy Designation is intended to expedite development and review timelines when preliminary clinical evidence indicates that a drug may demonstrate substantial improvement on one or more clinically significant endpoints over available therapies for serious or life threatening diseases. If approved by the FDA, SYN-004 (ribaxamase) would be the first available drug designed to prevent Clostridium difficile infection by protecting the gut microbiome from antibiotic-mediated dysbiosis.

“We are delighted by the FDA’s recognition of ribaxamase’s potential to prevent CDI, and the dire need to fill the current void of an approved intervention,” said Jeffrey Riley, President and Chief Executive Officer. “Following this announcement, we have been asked and anticipate requesting a Type-B multidisciplinary meeting with the Agency for a comprehensive discussion on the overarching, high-level drug development plan and pathway to licensure for ribaxamase. We look forward to working closely with the FDA throughout the development and review process and remain dedicated to bringing this potentially paradigm-shifting approach to antibiotic therapy to patients in critical need.”

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C. diff. Spores and More Global Broadcasting Network 

www.cdiffradio.com

Protecting the Gut Microbiome: A Paradigm Shift in Managing GI Disorders

Live Broadcast On Tuesday, May 16th Join us with our guest, Dr. Joseph Sliman, MD, MPH, Chief Medical Officer of Synthetic Biologics.  Dr. Sliman will be discussing  the protection of the natural gut microbiome from the unintended consequences of intravenous (IV) antibiotics which are excreted into the gut is expected to protect against opportunistic enteric infections. Synthetic Biologics is developing two microbiome-focused drug candidates in Phase 3 development including, SYN-004 (ribaxamase) which is designed to protect the gut microbiome by degrading certain IV beta-lactam antibiotics for the prevention of Clostridium difficile infection (CDI), pathogenic
overgrowth and the emergence of antimicrobial resistance, and SYN-010 which is intended to reduce the impact of methane producing organisms in the gut microbiome to treat an underlying cause of irritable bowel syndrome with constipation (IBS-C).

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To learn more about Synthetic Biologics, please click on the link provided below

.http://www.syntheticbiologics.com/about/overview

Source:  Synthetic Biologics

Synthetic Biologics – Protecting the Gut Microbiome: A Paradigm Shift in Managing GI Disorders

Researchers Suggest a Portion Of C. diff. Cases In Europe Involve Infections Associated With Other Sources Outside of Healthcare-Associated Infections

As part of a multicenter study, investigators from the University of Oxford, the University of Leeds, Astellas Pharma Europe, and elsewhere used a combination of ribotyping, sequencing, phylogenetics, and geographic analyses to retrace the genetic diversity and potential sources of C. difficile isolates involved in infections in European hospitals.

Recent research suggests a proportion of Clostridium difficile cases in Europe involve not only hospital-acquired infections but also infections associated with other sources, such as food.

As stated in the article:

https://www.genomeweb.com/sequencing/clostridium-difficile-genetic-patterns-europe-point-possible-infection-sources-beyond?utm_source=Sailthru&utm_medium=email&utm_campaign=GWDN%20Mon%20PM%202017-04-24&utm_term=GW%20Daily%20News%20Bulletin

David Eyre, a clinical lecturer at the University of Oxford, was slated to present the work at the European Congress of Clinical Microbiology and Infectious Diseases annual 2017 meeting in Vienna this past weekend. The study was funded by Astellas Pharma’s Europe, Middle East, and Africa (EMEA) program.

“We don’t know much about how C. difficile might be spread in the food chain, but this research suggests it may be very widespread,” Eyre said in a statement. “If that turns out to be the case, then we need to focus on some new preventative strategies such as vaccination in humans once this is possible, or we might need to look at our use of animal fertilizers on crops.”

“This study doesn’t give us any definitive answers,” he explained, “but it does suggest other factors [than hospital infections] are at play in the spread of C. difficile and more research is urgently needed to pin them down.”

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Some of the strains clustered by locale, consistent with spread from one individual to the next, for example in a healthcare setting. But more unexpectedly, the team also saw strains smattered across seemingly unconnected sites. And because at least one of those strains had previously been linked to pig farming, the researchers speculated that some infections may have been transmitted through food sources.

 

To read the article in its entirety click on the following link:

https://www.genomeweb.com/sequencing/clostridium-difficile-genetic-patterns-europe-point-possible-infection-sources-beyond?utm_source=Sailthru&utm_medium=email&utm_campaign=GWDN%20Mon%20PM%202017-04-24&utm_term=GW%20Daily%20News%20Bulletin